It is well known that many pathophysiological findings in toxemia of pregnancy are explained by imbalance of blood coagulation and fibrinolysis system. The purpose of this study is to clarify a precise role of blood coagulation and fibrinolysis
system
in the pathogenesis of toxemia of pregnancy.
Antithrombin III(AT-III) activity as blood coagulation parameter, and α2-plasmin inhibitor (α2-PI) activity as blood fibrinolysis parameter were measured in the plasma of toxemic patients by colorimetric analysis, and compared by normal
pregnant
controls. The results were as follows:
1. the mean plasma AT-III activity levels of normal pregnancy, mild preeclampsia and severe preeclampsia group were 112.9±18.4%, 105.2±18.4% and 87.3±10.85 respectively. the level of preeclampsia group was lower than that of normal pregnancy
group
significantly. And the level of severe preeclampsia group was lower than that of mild preeclampsia group.
2. The mean plasma α2-PI activity levels of normal pregnancy, mild preeclampsia and severe preeclampsia group were 108.2±12.0%, 96.6±14.8% and 95.5±11.0% respectively. the level of preeclampsia group was lower than that of normal pregnancy
group
significantly. But there was no significant difference between mild and severe preeclampsia group.
these findings suggest that, in toxemic pregnancy, the coagulation system dominate the fibrinolytic system as severity of toxemia increases. And so, hypercoaguability may play na important role in the pathogenesis of toxemia of pregnancy.
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